Author

Shirin Kappelhoff

Norwegian University of Science and TechnologyORCID 0009-0001-5857-1178Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Alfredo Cabrera‐OreficeiD· 1 shared Ana J. García Sáez· 1 shared Anne Marstad· 1 shared Asma MajouliD· 1 shared Christina KunziD· 1 shared Eleonora Germana MargheritisiD· 1 shared Gerhard HummeriD· 1 shared Jonathan C. KaganiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Alfredo Cabrera‐OreficeORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintSep 30, 2026

Structural mechanism of Gasdermin E-mediated mtDNA release from apoptotic mitochondria

Lisa Hohorst, Raed Shalaby, Nadine Gehle…·Ana J. García Sáez

This study identifies GSDME-N as a mediator of mitochondrial inner membrane permeabilization and mtDNA release during apoptosis, revealing its structural mechanism and impact on inflammatory responses.

DOI 10.64898/2026.09.29.755391

experimental assay

𝕏 PostBluesky

MicrobiologybioRxivPreprintNov 4, 2025

NINJ1 mediates necrosis of Mycobacterium tuberculosis infected human macrophages

Ragnhild SR Sætra, Mathilde Hansen, Shirin Kappelhoff…·Trude Helen Flo

This study identifies NINJ1 as a mediator of plasma membrane rupture in Mtb-infected macrophages, showing it operates independently of canonical cell death pathways and requires the ESX-1 secretion system.

3 citations

humanexperimental assay

𝕏 PostBluesky