Dark Microglia Are Abundant in Normal Postnatal Development, where they Remodel Synapses via Phagocytosis and Trogocytosis, and Are Dependent on TREM2
Haley A. Vecchiarelli, Kanchan Bisht, Kaushik P. Sharma, Sammy Weiser Novak, Marianela Evelyn Traetta, Monica Emili Garcia‐Segura, Marie‐Kim St‐Pierre, Julie C. Savage, Cory M. Willis, Katherine Picard, Maude Bordeleau, Nathalie Vernoux, Mohammadparsa Khakpour, Rishika Garg, Sophia M. Loewen, , Marie‐Ève Tremblay
This study identifies dark microglia in postnatal mouse hippocampus, showing they perform synapse remodeling via phagocytosis and trogocytosis and depend on TREM2.
bioRxiv · Oct 15, 2024 · PreprintNeuroscience