Deacetylation of catalytic lysine in CDK1 is essential for Cyclin-B binding and cell cycle
Shaunak Deota, Sivasudhan Rathnachalam, Kanojia Namrata, Mayank Boob, Amit Fulzele, S Radhika, Shubhra Ganguli, Chinthapalli Balaji, Stephanie Kaypee, Krishna Kant Vishwakarma, Tapas Kumar Kundu, Rashna Bhandari, Anne Gonzalez de Peredo, Mithilesh Mishra, Ravindra Venkatramani, Ullas Kolthur-Seetharam
This study shows that acetylation of catalytic lysine in CDK1 regulates Cyclin-B binding, with SIRT1 and P300 opposing this modification, and that acetylation mimics in yeast block cell cycle progression.
bioRxiv · Sep 20, 2018 · PreprintCell Biology