Estrogens increase cancer cell efferocytosis to establish an immunosuppressive tumor microenvironment
Binita Chakraborty, Prabuddha Chakraborty, Michael C. Brown, Daniel Crowder, Aditi Goyal, Rachid Safi, Sandeep Artham, Megan Kirkland, Alessandro Racioppi, Patrick K. Juras, Debarati Mukherjee, Felicia Lim, Jovita K. Byemerwa, Kiana A. Gunn, Scott Floyd, , Donald Patrick McDonnell
This study shows that estrogens enhance tumor-associated macrophage efferocytosis, promoting immunosuppression, and demonstrates that targeting the E2/ER/CX3CR1 axis can reverse this effect and improve radiation therapy.
bioRxiv · Dec 26, 2024 · PreprintCancer Biology