Ching‐yi Chang

Dietary methionine restriction primes T cell metabolism for activation and tumor inhibition and enhances the efficacy of immune checkpoint blockade

This study shows that dietary methionine restriction enhances T cell metabolism and improves anti-PD1 checkpoint blockade efficacy in immunocompetent tumor models.

Estrogens increase cancer cell efferocytosis to establish an immunosuppressive tumor microenvironment

This study shows that estrogens enhance tumor-associated macrophage efferocytosis, promoting immunosuppression, and demonstrates that targeting the E2/ER/CX3CR1 axis can reverse this effect and improve radiation therapy.