Melissa Deshors

A minor impact of VGLUT1 expression level on quantal size revealed through the characterization of VGLUT1mEos2 knock-down new mouse model

The paper characterizes a VGLUT1 knock-down mouse model and finds that reduced VGLUT1 expression does not significantly affect quantal size or frequency of glutamate release.

Mammalian vesicular glutamate transporter VGLUT1 reduces synaptic vesicle superpool size and spontaneous release frequency.

The paper identifies a mechanism by which VGLUT1 increases synaptic vesicle clustering, reducing superpool size and spontaneous release frequency through interactions with endophilinA1 and intersectin1.