ACSS2 upregulation enhances neuronal resilience to aging and tau-associated neurodegeneration
Naemeh Pourshafie, Desi C. Alexander, Hong Wei Xu, Kechun Yang, Greg Donahue, Xue Lei, Shuo Zhang, Oksana Shcherbakova, Connor Hogan, Michael Gilbert, Kevt’her Hoxha, Lesley S. Chaboub, Virginia M.‐Y. Lee, Peter D. Adams, John A. Dani, , Shelley L. Berger
This study shows that increasing ACSS2 levels protects neurons from age-related and tau-induced decline by enhancing synaptic and longevity gene expression.
Proceedings of the National Academy of Sciences · Jan 9, 2026Peer-reviewedNeuroscience