Author

Kechun Yang

University of PennsylvaniaORCID 0000-0002-5207-6870Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:electronic health records· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

John A. DaniiD· 3 shared Amelia J. EischiD· 1 shared Connor HoganiD· 1 shared Desi C. AlexanderiD· 1 shared Greg DonahueiD· 1 shared Hong Wei XuiD· 1 shared Jessica K. ShawiD· 1 shared Kevt’her Hoxha· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersNeuroscience

John A. DaniORCID

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3 papers

Recent·Most cited

Chronic Alcohol Exposure Alters Expression of GluN3A-NMDA Receptors in Adult VTA DA Neurons

Kechun Yang, Jessica K. Shaw, John A. Dani, Mariella De Biasi

This study shows chronic alcohol exposure increases GluN3A-containing NMDARs in VTA dopamine neurons, altering their biophysical properties and glycine responsiveness.

bioRxiv · Sep 10, 2026 · PreprintNeuroscience

ACSS2 upregulation enhances neuronal resilience to aging and tau-associated neurodegeneration

Naemeh Pourshafie, Desi C. Alexander, Hong Wei Xu, Kechun Yang, Greg Donahue, Xue Lei, Shuo Zhang, Oksana Shcherbakova, Connor Hogan, Michael Gilbert, Kevt’her Hoxha, Lesley S. Chaboub, Virginia M.‐Y. Lee, Peter D. Adams, John A. Dani, , Shelley L. Berger

This study shows that increasing ACSS2 levels protects neurons from age-related and tau-induced decline by enhancing synaptic and longevity gene expression.

Proceedings of the National Academy of Sciences · Jan 9, 2026Peer-reviewedNeuroscience

Paradoxical ventral tegmental area GABA signaling drives enhanced morphine reward after adolescent nicotine

Ruthie E. Wittenberg, Sanghee Yun, Kechun Yang, Olivia K. Swanson, Shannon L. Wolfman, Lorianna M. Colón, Amelia J. Eisch, John A. Dani

This study shows that adolescent nicotine exposure alters VTA GABA neuron responses to morphine, enhancing morphine reward in adulthood.

Biological Psychiatry · Jun 24, 2025Peer-reviewedNeuroscience