PADI2-mediated citrullination is required for efficient oligodendrocyte differentiation and myelination
Ana Mendanha Falcão, Mandy Meijer, Antonella Scaglione, Puneet Rinwa, Eneritz Agirre, Jialiang Liang, Sara Charlotte Buch-Larsen, Abeer Heskol, Rebecca Frawley, Michael Klingener, Manuel Varas‐Godoy, Alexandre A. S. F. Raposo, Patrik Ernfors, Diogo S. Castro, Michael Lund Nielsen, , Gonçalo Castelo‐Branco
This study shows that PADI2-mediated citrullination is essential for oligodendrocyte differentiation, myelination, and motor function, with implications for remyelination therapies.
Cell Reports · Apr 1, 2019Peer-reviewedNeuroscience