Author

Alexandre A. S. F. Raposo

Instituto Gulbenkian de CiênciaORCID 0000-0002-2794-0508Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Abeer Heskol· 1 shared Ana Mendanha FalcãoiD· 1 shared Ana Rita GrossoiD· 1 shared Antonella ScaglioneiD· 1 shared Catarina G FonsecaiD· 1 shared Claudio Areias FrancoiD· 1 shared Diogo S. CastroiD· 1 shared Eneritz AgirreiD· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Abeer Heskol

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2 papers

Recent·Most cited

Alternative splicing changes are associated with pre-birth adaptation during lung development

Marta Fidalgo, Catarina G Fonseca, Paulo Caldas, Alexandre A. S. F. Raposo, Tania Balboni, Ana Rita Grosso, Francisca F. Vasconcelos, Claudio Areias Franco

The paper identifies cell type-specific alternative splicing changes in lung development, particularly in Vegfa, that may prepare the lung for postnatal function.

bioRxiv · Jan 19, 2022 · PreprintDevelopmental Biology

PADI2-mediated citrullination is required for efficient oligodendrocyte differentiation and myelination

Ana Mendanha Falcão, Mandy Meijer, Antonella Scaglione, Puneet Rinwa, Eneritz Agirre, Jialiang Liang, Sara Charlotte Buch-Larsen, Abeer Heskol, Rebecca Frawley, Michael Klingener, Manuel Varas‐Godoy, Alexandre A. S. F. Raposo, Patrik Ernfors, Diogo S. Castro, Michael Lund Nielsen, , Gonçalo Castelo‐Branco

This study shows that PADI2-mediated citrullination is essential for oligodendrocyte differentiation, myelination, and motor function, with implications for remyelination therapies.

Cell Reports · Apr 1, 2019Peer-reviewedNeuroscience