Eneritz Agirre

This study shows FGF signaling induces disease-associated oligodendrocyte states and causes myelin pathology in both in vitro and in vivo models.

This paper identifies FABP8/PMP2 as a defining feature of human and old-world monkey CNS myelin, revealing molecular heterogeneity in myelin sheaths and its role in cholesterol enrichment.

The paper shows that oligodendrocyte precursor cells (OPCs) use activity-dependent vesicular release to stabilize retinal ganglion cell pre-synapses in zebrafish.

This study shows GABAB receptors have dual roles in oligodendrocyte function and immune modulation in experimental MS, with baclofen showing therapeutic potential in reducing disease severity and promoting remyelination.

The paper performs multi-omics analysis of choroid plexus across development in mice and rats, identifying cellular remodeling, immune gene activation, and a novel epithelial subtype.

The paper uses single nuclei RNAseq to identify distinct glial gene expression patterns in MS patients, revealing subgroup-specific pathological processes and suggesting precision medicine approaches.

This study identifies TAF1-dependent transcriptional dysregulation as a mechanism underlying multiple sclerosis progression and presents an in vivo model for therapeutic development.

The paper profiles histone modifications in adult human CNS cells, revealing epigenetic memory of developmental programs in oligodendroglia.

The paper introduces NicheCompass, a graph deep learning method for characterizing cell niches in spatial omics data, showing improved performance in identifying and analyzing niches across multiple biological contexts.

This study identifies a primed chromatin state in oligodendroglia that facilitates rapid activation of immune gene programs in multiple sclerosis.

RADICL-seq maps genome-wide RNA-chromatin interactions in intact nuclei, revealing general and cell type-specific patterns of transcript occupancy and the role of transcription in chromatin structure.

The paper identifies two functionally distinct subgroups of OPCs in zebrafish spinal cord, showing activity-dependent proliferation and differentiation.

This study shows that PADI2-mediated citrullination is essential for oligodendrocyte differentiation, myelination, and motor function, with implications for remyelination therapies.