Benjamin G. Neel

Proteogenomic analysis of up to 11 CPTAC cohorts shows ubiquitin-proteasome proteins often diverge from transcripts; TP53-mutant tumors elevate UBR5 protein, while TRIM28 prognosis is lineage-dependent.

This paper identifies a PTP activity-independent mechanism by which SHP2 promotes RAS/ERK activation through direct binding to SOS1.

This study shows that deleting SHP1 and SHP2 in T cells increases CD4+ T cell activation-induced cell death and reduces antitumor responses, with SHP2 loss enhancing anti-PD-1 therapy.

The paper introduces a segmentation-free vision transformer, CANVAS, to discover and characterize tumor microenvironment signatures from high-dimensional multiplexed images, identifying a monocytic signature linked to poor prognosis.

This study identifies a 24-protein panel distinguishing TNBC from other breast cancers and shows proteomics improves drug sensitivity predictions.

This study compares proliferation and migration transcriptomic signatures in breast cancer, finding migration is more strongly linked to patient survival.