John Thomas Poirier

This study identifies genotype-specific immune and metabolic vulnerabilities in lung adenocarcinoma through cross-species analysis of human and mouse tumors.

This study identifies EGFR mutations conferring resistance to BLU-945 using deep mutational scanning and shows that combination treatment may suppress resistance mechanisms.

This paper enhances the Eco1 retron editor for precise genome editing in human cells by improving ncRNA stability and reducing sgRNA extension, achieving editing without double-strand breaks.

The paper identifies PLSCR1 as a host factor restricting SARS-CoV-2 entry, which recent variants have evolved to bypass, through a CRISPR screen and integration of genetic studies.

This study identifies inflammation in tumor-adjacent lung tissue as a predictor of clinical outcome in lung adenocarcinoma using multi-omic analysis of 143 stage I cases.

The paper identifies TMEM41B as a host factor required for flavivirus infection and shows SNPs in TMEM41B reduce infection in East Asian populations.

ProteomeGenerator enables sample-specific proteome discovery by integrating transcriptome sequencing and high-accuracy mass spectrometry, identifying non-canonical protein isoforms and improving proteogenomic analysis.