René Hägerling

Engineered endothelial cell grafts form functional anastomoses and enable recruitment of intravenously delivered human T cells in CAM tumor models

This paper develops an endothelial graft-enhanced CAM tumor model to study T cell recruitment and activation in human cancer immunotherapy.

Nanobody immunolabelling and three-dimensional imaging reveals spatially restricted LYVE1 expression by kidney lymphatic vessels in mice

The paper develops a nanobody-based method to label kidney lymphatic vessels in mice, revealing spatially restricted LYVE1 expression unique to the kidney.

Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene program in bat wing development

The paper compares bat and mouse limb development using single-cell analyses to show how a conserved gene program is repurposed in bat wing formation.

Fetal Liver-like Organoids Recapitulate Blood-Liver Niche Development and Multipotent Hematopoiesis from Human Pluripotent Stem Cells

Mesenchymal Osr1+ cells regulate embryonic lymphatic vessel formation

This study identifies mesenchymal Osr1+ cells as regulators of embryonic lymphatic vessel formation by controlling LEC proliferation and migration.

Single cell, whole embryo phenotyping of pleiotropic disorders of mammalian development

The paper uses single-cell RNA sequencing to systematically phenotype mouse genetic models, identifying molecular and cellular changes across multiple mutants and wildtypes.