Multivalent Anti-ACE2 Nanobodies Confer Broad Pan-Sarbecovirus Protection
Athanasios D. Bakasis, Rachel Patejak, Peter C. Fridy, Jesse Jenkins, Miranda Aldis, Viren A. Baharani, Lakshmi Sriram, Kelly R. Molloy, Brian T. Chait, Michael P. Rout, Frederick R. Cross, Paul D. Bieniasz, Théodora Hatziioannou
This study develops multivalent anti-ACE2 nanobodies that broadly neutralize SARS-CoV-2 variants and sarbecoviruses with high potency and efficacy in animal models.
bioRxiv · Sep 3, 2026 · PreprintImmunology