Manivel Lodha

Genetic innovation in coronaviruses driven by a viral nuclease

This study shows that the coronavirus nuclease NSP15 drives insertion mutations, which can enhance viral transmissibility, as seen in the SARS-CoV-2 furin cleavage site.

Interferon-gamma induced RNF213 targets nascent double membrane vesicles to inhibit coronavirus primary translation

This study identifies RNF213 as an IFN-gamma-induced antiviral protein that inhibits coronavirus translation by targeting nascent double membrane vesicles.

Murine cytomegalovirus evolved a cell-cycle regulator (m54.5) within the highly conserved viral DNA polymerase gene

This study identifies m54.5 as a novel gene within the conserved MCMV DNA polymerase locus that encodes a protein regulating cell cycle arrest, with functional similarity to HCMV UL21a but not essential for viral replication.

Identifying Modulators of Cellular Responses by Heterogeneity-sequencing

Heterogeneity-seq identifies causal factors driving heterogeneous cellular responses by combining single-cell RNA-seq with metabolic labeling and double machine learning.

Correcting 4sU induced quantification bias in nucleotide conversion RNA-seq data

The paper develops computational methods to correct 4sU-induced quantification bias in nucleotide conversion RNA-seq data by addressing mappability and reverse transcription efficiency issues.