Michael P. Rout

This study develops multivalent anti-ACE2 nanobodies that broadly neutralize SARS-CoV-2 variants and sarbecoviruses with high potency and efficacy in animal models.

The paper identifies a novel phosphorylated NES in Pho4 recognized by Msn5, revealing a phosphate-specific nuclear export mechanism in yeast.

This study uses structural biology to reveal the architecture of the nuclear basket in yeast and mammals, showing how Mlp/Tpr proteins form its structural components.

This paper develops and characterizes 50 nm diameter genetically encoded multimeric nanoparticles (GEMs) for improved nanorheology studies.

The paper uses site-specific deuteration and SANS to study the dynamic structure of FG Nups interacting with NTF2, revealing their fully disordered nature and lack of significant inter-aromatic contacts.

The paper identifies Crm1 as an adaptor that links transcription factors to chromatin at the nuclear pore complex, facilitating enhancer docking.

This paper introduces CTCC, a method using cryomilling to map chromatin interactions, showing it can generate global contact maps similar to Hi-C but with enhanced signal for stable inter-chromosomal contacts.

The paper identifies distinct nuclear and cytoplasmic intermediates of LINE-1 retrotransposition using mass spectrometry and affinity purification.

This paper introduces a rapid method for isolating well-preserved yeast nuclei, enabling detailed structural and functional studies.