Théodora Hatziioannou

Multivalent Anti-ACE2 Nanobodies Confer Broad Pan-Sarbecovirus Protection

This study develops multivalent anti-ACE2 nanobodies that broadly neutralize SARS-CoV-2 variants and sarbecoviruses with high potency and efficacy in animal models.

Genetic innovation in coronaviruses driven by a viral nuclease

This study shows that the coronavirus nuclease NSP15 drives insertion mutations, which can enhance viral transmissibility, as seen in the SARS-CoV-2 furin cleavage site.

Interferon-gamma induced RNF213 targets nascent double membrane vesicles to inhibit coronavirus primary translation

This study identifies RNF213 as an IFN-gamma-induced antiviral protein that inhibits coronavirus translation by targeting nascent double membrane vesicles.

A designed overlapping variant immunogen pool elicits broad sarbecovirus neutralization

This paper designs an overlapping variant immunogen pool that elicits broad neutralization against SARS-CoV-2 variants and a chimeric SARS-CoV-1 virus.

HIV-1 Integration Site Determines the Transcriptional Fate and Persistence of Integrated Proviruses

This study investigates how HIV-1 integration sites influence viral latency and clonal expansion in human memory CD4+ T cells engrafted into mice.

Memory B cell Development in Response to mRNA SARS-CoV-2 and Nanoparticle Immunization in Mice

This study compares memory B cell responses to mRNA and nanoparticle vaccines in mice, finding similar antibody sequences but better breadth from mosaic nanoparticle vaccines.

Clonal Expansion and Diversification of Germinal Center and Memory B Cell Responses to Booster Immunization in Primates

This study examines memory and germinal center B cell responses in rhesus macaques after booster immunization, finding that high affinity memory B cells form a reservoir that participates in immune development regardless of boosting site.

Cross-reactive sarbecovirus antibodies induced by mosaic RBD-nanoparticles

This paper develops mosaic RBD-nanoparticles to induce cross-reactive anti-sarbecovirus antibodies in animals, demonstrating their effectiveness against SARS-CoV-2 variants and zoonotic viruses.