Marie Canis

A designed overlapping variant immunogen pool elicits broad sarbecovirus neutralization

This paper designs an overlapping variant immunogen pool that elicits broad neutralization against SARS-CoV-2 variants and a chimeric SARS-CoV-1 virus.

Dynamic Antigen Expression and Intrinsic CTL Resistance in HIV Reservoir Clones

This study characterizes HIV reservoir clones and shows they can be culled by sustained CTL pressure, with some displaying intrinsic resistance linked to low oxidative stress.

HIV-1 Integration Site Determines the Transcriptional Fate and Persistence of Integrated Proviruses

This study investigates how HIV-1 integration sites influence viral latency and clonal expansion in human memory CD4+ T cells engrafted into mice.

PRISM-Seq: An Ultra-sensitive Sequencing Approach For Mapping Lentiviral Integration Sites

PRISM-seq is an ultra-sensitive method for detecting lentiviral integration sites, validated at the single-molecule level with a quality control framework to reduce artifacts.

Memory B cell Development in Response to mRNA SARS-CoV-2 and Nanoparticle Immunization in Mice

This study compares memory B cell responses to mRNA and nanoparticle vaccines in mice, finding similar antibody sequences but better breadth from mosaic nanoparticle vaccines.

Clonal Expansion and Diversification of Germinal Center and Memory B Cell Responses to Booster Immunization in Primates

This study examines memory and germinal center B cell responses in rhesus macaques after booster immunization, finding that high affinity memory B cells form a reservoir that participates in immune development regardless of boosting site.