Author

Thomas Reinheckel

University of FreiburgORCID 0000-0001-9866-9105Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Thomas Reinheckel1 paper

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Andrea Ahles· 1 shared Anika ReifschneideriD· 1 shared Anja CapelliD· 1 shared Björn BartelsiD· 1 shared Christian HaassiD· 1 shared Christine Van BroeckhoveniD· 1 shared Claudia Krenner· 1 shared Dieter EdbaueriD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Andrea Ahles

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2 papers

Recent·Most cited

Enhanced legumain activity links progranulin deficiency to TDP-43 pathology in frontotemporal lobar degeneration

Sophie Robinson, Marvin Reich, Maria‐Teresa Mühlhofer, Katrin Buschmann, Eline Wauters, Quirin Mühlhofer, Georg Werner, Andrea Ahles, Stefan Hanns Engelhardt, Claudia Krenner, Björn Bartels, Simon Gutbier, Anika Reifschneider, Henrick Riemenschneider, Thomas Reinheckel, , Anja Capell

This study shows that reduced progranulin leads to increased legumain activity, which promotes TDP-43 pathology in FTLD, suggesting legumain as a therapeutic target.

bioRxiv · Jan 16, 2024 · PreprintNeuroscience

Differential regulation of progranulin derived granulin peptides

Tingting Zhang, Huan Du, Mariela Nunez Santos, Xiaochun Wu, Mitchell D. Pagan, Lianne Jillian Trigiani, Nozomi Nishimura, Thomas Reinheckel, Fenghua Hu

The paper identifies differential regulation of specific granulin peptides and their glycosylation patterns in relation to lysosomal protease activity and physiological/pathological conditions.

Molecular Neurodegeneration · Feb 4, 2022Peer-reviewedNeuroscience