TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice
Yuanyuan Wang, Tiffany Z. Wu, Ming‐Chi Tsai, Mitchell G. Rezzonico, Alyaa M. Abdel‐Haleem, Luke Xie, Vineela D. Gandham, Hai Ngu, Kimberly L. Stark, Caspar Glock, Daqi Xu, Oded Foreman, Brad A. Friedman, Morgan Sheng, Jesse E. Hanson
This study shows that TPL2 kinase activity in microglia drives neuroinflammation and neurodegeneration in tauopathy models, suggesting it as a therapeutic target.
eLife · Jul 31, 2023Peer-reviewedNeuroscience