Transient architecture of the embryonic pancreas determines endocrine mass
Ondine B. Cleaver, Neha Ahuja, Christopher P. Chaney, Tyler Bierschenk, Tuli Pramanik, Austin Mills, Peter Luo, Mitzy Cowdin, Jinlong Lin, Jun Tsunezumi, Kevin M. Dean, Denise Marciano, Thomas J. Carroll
This study shows that transient 3D epithelial architecture in the embryonic pancreas instructs lineage allocation and endocrine cell mass formation through Merlin-dependent membrane trafficking.
bioRxiv · Jul 1, 2026 · PreprintDevelopmental Biology