Author

Jun Tsunezumi

Kanagawa Cancer CenterORCID 0000-0001-9962-2149Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Aiko SadaiD· 2 shared Christopher P. ChaneyiD· 2 shared Erna RajaiD· 2 shared Hiromi YanagisawaiD· 2 shared Thomas J. CarrolliD· 2 shared Asm Sakhawat HossainiD· 1 shared Austin Mills· 1 shared Denise K. MarcianoiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

Aiko SadaORCID

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Author profile →

4 papers

Recent·Most cited

The epidermal stem cell-supporting matricellular protein fibulin 7 modulates skin inflammatory response in a psoriasis model

Erna Raja, Tomoko Machida, Narenmandula Narenmandula, Karolina Edlund, Asm Sakhawat Hossain, Wenxin Fan, Jun Tsunezumi, Yukihide Watanabe, Marina Sanaki-Matsumiya, Keiichi Asano, Kenichi Kimura, Ken Natsuga, Aiko Sada, Hiromi Yanagisawa

This study shows fibulin 7 protects against skin inflammation by modulating IL-17A signaling in a psoriasis model.

Cellular and Molecular Life Sciences · Oct 31, 2026Peer-reviewedCell Biology

Transient architecture of the embryonic pancreas determines endocrine mass

Ondine B. Cleaver, Neha Ahuja, Christopher P. Chaney, Tyler Bierschenk, Tuli Pramanik, Austin Mills, Peter Luo, Mitzy Cowdin, Jinlong Lin, Jun Tsunezumi, Kevin M. Dean, Denise Marciano, Thomas J. Carroll

This study shows that transient 3D epithelial architecture in the embryonic pancreas instructs lineage allocation and endocrine cell mass formation through Merlin-dependent membrane trafficking.

bioRxiv · Jul 1, 2026 · PreprintDevelopmental Biology

Epithelial tubule interconnection driven by HGF-Met signaling in the kidney

Isabel A. López-García, Sunhee Oh, Christopher P. Chaney, Jun Tsunezumi, Iain A. S. Drummond, Leif H. Oxburgh, Thomas J. Carroll, Denise K. Marciano

This study identifies HGF as a key inducer of epithelial tubule anastomosis in vitro and in embryonic kidneys, revealing a proliferation-independent mechanism involving MAPK and MMPs.

Proceedings of the National Academy of Sciences · Dec 20, 2024Peer-reviewedDevelopmental Biology

The extracellular matrix fibulin 7 maintains epidermal stem cell heterogeneity during skin aging

Erna Raja, Gopakumar Changarathil, Lalhaba Oinam, Yen Xuan Ngo, Jun Tsunezumi, Ryutaro Ishii, Takako Sasaki, Kyoko Imanaka‐Yoshida, Hiromi Yanagisawa, Aiko Sada

This study shows that fibulin 7 maintains epidermal stem cell heterogeneity during skin aging by preserving fast-cycling clones and preventing inflammation-related gene expression.

EMBO Reports · Oct 24, 2022Peer-reviewedDevelopmental Biology