Chemotherapy Induces an IL1β-dependent Neutrophil Recruitment that Promotes Chemoresistance in Metastatic Ovarian Cancer
Taito Miyamoto, Yujie Ye, Bryan S. Manning, Brennah Murphy, Moeko Minakuchi, Kohei Hamada, Rin Mizuno, Mana Taki, Koji Yamanoi, Ryusuke Murakami, Masaki Mandai, Ying Ye, Jayamanna M. Wickramasinghe, Yulia Nefedova, Andrew V. Kossenkov, Nan Zhang
This study shows chemotherapy induces IL1β-dependent neutrophil recruitment, promoting chemoresistance in metastatic ovarian cancer through NETs and immune modulation.
bioRxiv · Sep 21, 2025 · PreprintImmunology