HSP-1-Specific Nanobodies Alter Chaperone Function in vitro and in vivo
Nicholas D. Urban, Kunal Gharat, Zachary Mattiola, Ashley Scheutzow, Adam Klaiss, Sarah Tabler, Asa W. Huffaker, Monique Grootveld, Mary E. Skinner, Weiyang Zheng, Matthew J. O’Meara, Janine Kirstein, Matthias C. Truttmann
This study develops two nanobodies that specifically target HSP-1, reducing its ATPase activity and protein folding capacity both in vitro and in vivo.
Journal of Biological Chemistry · Feb 4, 2026Peer-reviewedBiochemistry