Author

Zachary Mattiola

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Adam KlaissiD· 2 shared Matthias C. TruttmanniD· 2 shared Nicholas D. UrbaniD· 2 shared Sarah Tabler· 2 shared Asa W. Huffaker· 1 shared Ashley Scheutzow· 1 shared Benedict AbdoniD· 1 shared Janine KirsteiniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Adam KlaissORCID

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Author profile →

2 papers

Recent·Most cited

HSP-1-Specific Nanobodies Alter Chaperone Function in vitro and in vivo

Nicholas D. Urban, Kunal Gharat, Zachary Mattiola, Ashley Scheutzow, Adam Klaiss, Sarah Tabler, Asa W. Huffaker, Monique Grootveld, Mary E. Skinner, Weiyang Zheng, Matthew J. O’Meara, Janine Kirstein, Matthias C. Truttmann

This study develops two nanobodies that specifically target HSP-1, reducing its ATPase activity and protein folding capacity both in vitro and in vivo.

Journal of Biological Chemistry · Feb 4, 2026Peer-reviewedBiochemistry

Functionally diversified BiP orthologs control body growth, reproduction, stress resistance, aging, and ER-Phagy in Caenorhabditis elegans.

Nicholas D. Urban, Shannon M. Lacy, Kate M. Van Pelt, Benedict Abdon, Zachary Mattiola, Adam Klaiss, Sarah Tabler, Matthias C. Truttmann

This study shows how two HSP70 chaperones in C. elegans, HSP-3 and HSP-4, have distinct and overlapping roles in ER proteostasis, affecting growth, reproduction, stress resistance, aging, and ER-Phagy.

bioRxiv · Jan 14, 2025 · PreprintPhysiology