Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brain
Meenakshi Chakraborty, Sophia M. Shi, Imani E. Porter, Daniel J. Richard, Georgi K. Marinov, Mukundh N. Murthy, Ashley A. Moore, Jenna Lynn Elizabeth Blum, Aravind Natarajan, James W.S. Jahng, Joseph C. Wu, Sydney X. Lu, Shawn M. Davidson, William James Greenleaf, Nay Lui Saw, , Ami Siddharth Bhatt
The paper identifies age-related microbiome metabolites that alter RNA splicing and chromatin accessibility in the mouse brain using metabolomics, transcriptomic, and multi-omic approaches.
bioRxiv · Oct 3, 2025 · PreprintNeuroscience