Iron addicted colorectal cancers exploit Heme-Complex II axis to resist oxidative cell death
Chesta Jain, Muqit Essani, Roshan Kumar, Nupur Kanti Das, Rashi Singhal, Nicholas J. Rossiter, Brandon Chen, Wesley Huang, Zheng Hong Lee, Sumeet A. Solanki, Yuezhong Zhang, Peter Sajjakulnukit, Li Zhang, Prarthana Dalal, David A. Hanna, , Yatrik Madhukar Shah
This study identifies a heme-SDH-CoQ axis that helps colorectal cancer cells resist iron-induced oxidative stress and cell death.
Cell Metabolism · May 27, 2026Peer-reviewedCancer Biology