Roshan Kumar

Hydrogen sulfide dynamically upregulates copper uptake and localization

This study shows hydrogen sulfide increases copper uptake and localization in cells, with copper primarily in the Cu2+ state, using the ZNT1 transporter for import and ATP7A for export.

Iron addicted colorectal cancers exploit Heme-Complex II axis to resist oxidative cell death

This study identifies a heme-SDH-CoQ axis that helps colorectal cancer cells resist iron-induced oxidative stress and cell death.

Fatty acids in the tumor microenvironment reprogram neutrophils to induce immunosuppression via adenosine

This study identifies a fatty acid-driven neutrophil-adenosine axis that promotes immunosuppression in colorectal cancer and shows that targeting adenosine receptors can enhance immunotherapy responses.

Hydrogen sulfide increases intracellular oxygen and regulates the HIF response

This study shows hydrogen sulfide increases intracellular oxygen and destabilizes HIF-1, altering hypoxia sensing and potentially contributing to O2 toxicity diseases.

Gut sulfide metabolism modulates behavior and brain bioenergetics

This study shows that gut SQOR deficiency and high dietary methionine impair colon bioenergetics, alter microbiome, and affect brain function and behavior.