Elena M. Stoffel

Iron addicted colorectal cancers exploit Heme-Complex II axis to resist oxidative cell death

This study identifies a heme-SDH-CoQ axis that helps colorectal cancer cells resist iron-induced oxidative stress and cell death.

Fatty acids in the tumor microenvironment reprogram neutrophils to induce immunosuppression via adenosine

This study identifies a fatty acid-driven neutrophil-adenosine axis that promotes immunosuppression in colorectal cancer and shows that targeting adenosine receptors can enhance immunotherapy responses.

Mutational signature profiling classifies subtypes of clinically different mismatch repair deficient tumors with a differential immunogenic response potential

This study classifies MMR-deficient tumors into subtypes based on mutational signatures and immunogenic potential, revealing clinical and molecular differences.