Wesley Huang

CRISPR/Cas9 knockout and editing of the major cysteine protease in Entamoeba histolytica

This study develops CRISPR/Cas9 for endogenous genome editing in Entamoeba histolytica, targeting the virulence factor CP5 and advancing genetic tools for the parasite.

Iron addicted colorectal cancers exploit Heme-Complex II axis to resist oxidative cell death

This study identifies a heme-SDH-CoQ axis that helps colorectal cancer cells resist iron-induced oxidative stress and cell death.

Fatty acids in the tumor microenvironment reprogram neutrophils to induce immunosuppression via adenosine

This study identifies a fatty acid-driven neutrophil-adenosine axis that promotes immunosuppression in colorectal cancer and shows that targeting adenosine receptors can enhance immunotherapy responses.

Aspartate transaminases are required for blood development

This study identifies aspartate transaminases GOT1 and GOT2 as critical for erythropoiesis by linking metabolism to epigenetic regulation, revealing a novel role in blood development.

Cross-species protection suggests Entamoeba histolytica trogocytosis enables complement resistance through the transfer of negative regulators of complement activation

The paper shows that Entamoeba histolytica uses trogocytosis to acquire and display human complement regulators, enabling resistance to complement lysis even when exposed to mouse serum.

Fmo5 plays a sex-specific role in goblet cell maturation and mucus barrier formation

This study identifies Fmo5's sex-specific role in goblet cell maturation and mucus barrier formation in the intestine, with severe effects in female mice.