Deep phenotyping and multi-omics analyses reveal systems-wide metabolic dysregulation in a refined trisomy mouse model of Down syndrome
Muzna Saqib, Fangluo Chen, Diya K Mistri, Laura Tan, Noelle Wright, Dylan C. Sarver, Robert A. Anders, Susan M. Aja, Guang William Wong
The paper compares metabolic dysregulation in two Down syndrome mouse models, finding Ts66Yah exhibits more severe metabolic disturbances than Ts65Dn.
bioRxiv · Aug 29, 2026 · PreprintPhysiology