Author

N. C. Morano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Organism:Drosophila· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

A. B. Massimi· 2 shared A. Celikgil· 2 shared A. P. Sergeeva· 2 shared B. Honig· 2 shared J. H. Lee· 2 shared L. Shapiro· 2 shared N. G. Herrera· 2 shared P. S. Katsamba· 2 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

A. B. Massimi

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Author profile →

4 papers

Recent·Most cited

Cis inhibition of co-expressed DIPs and Dprs shapes neural development

N. C. Morano, D. S. Lopez, H. Meltzer, A. P. Sergeeva, P. S. Katsamba, K. D. Rostam, H. P. Gupta, J. E. Becker, B. Bornstein, F. Cosmanescu, O. Schuldiner, B. Honig, R. S. Mann, L. Shapiro

The paper shows that DIPs and Dprs interact in cis within the same cells, regulating trans interactions and influencing neural development in Drosophila.

PLOS Biology · Mar 3, 2025Peer-reviewedBiochemistry

SARS-CoV-2 multi-antigen protein microarray for detailed characterization of antibody responses in COVID-19 patients

A. Celikgil, A. B. Massimi, A. Nakouzi, N. G. Herrera, N. C. Morano, J. H. Lee, H. a. Yoon, S. J. Garforth, S. C. Almo

This study develops a SARS-CoV-2 multi-antigen protein microarray to analyze antibody responses in COVID-19 patients, showing higher S IgG levels and reactivity to the S1 RBD but not S2 heptad repeat domain.

bioRxiv · Oct 14, 2022Biochemistry

Free energy perturbation calculations of mutation effects on SARS-CoV-2 RBD::ACE2 binding affinity

A. P. Sergeeva, P. S. Katsamba, J. M. Sampson, F. Bahna, S. Mannepalli, N. C. Morano, L. Shapiro, R. A. Friesner, B. Honig

This study uses free energy perturbation calculations to assess how mutations in SARS-CoV-2 RBD affect binding affinity to ACE2, showing FEP's superior accuracy in identifying stabilizing mutations.

bioRxiv · Aug 1, 2022Biophysics

Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis

N. G. Herrera, N. C. Morano, A. Celikgil, G. I. Georgiev, R. J. Malonis, J. H. Lee, K. Tong, O. Vergnolle, A. B. Massimi, L. Y. Yen, A. J. Noble, M. Kopylov, J. B. Bonanno, S. C. Garrett-Thomson, D. B. Hayes, , S. C. Almo

This study evaluates the production, characterization, and antigenicity of SARS-CoV-2 S protein constructs in two cell lines, showing high-quality yields and consistent behavior across assays.

bioRxiv · Jun 14, 2020Biochemistry