X. Zhi

Nociceptive neurons interact directly with gastric cancer cells via a CGRP/Ramp1 axis to promote tumor progression

The paper identifies a CGRP/Ramp1 axis-mediated interaction between nociceptive neurons and gastric cancer cells that promotes tumor progression.

Characterization of the RofA regulon in the pandemic M1global and emergent M1UK lineages of Streptococcus pyogenes

This study characterizes the RofA regulon in two emm1 lineages of Streptococcus pyogenes, showing lineage-specific gene expression changes and potential regulatory impacts of SNPs in the PRD domain.

Multi-continental detection of Streptococcus pyogenes M1UK: Impact of ssrA SNP on SpeA expression in ancestral and M1UK isolates

This study investigates the impact of an ssrA SNP on SpeA expression in Streptococcus pyogenes isolates, showing its role in enhancing SpeA production but not being the sole determinant.

Characterisation of emergent toxigenic M1UK Streptococcus pyogenes and associated sublineages

This study characterizes the M1UK sublineage of Streptococcus pyogenes, identifying genetic and phenotypic differences that contribute to its dominance and increased virulence.

Ongoing emergence of M1UK lineage among invasive group A streptococcus isolates in 2020 and use of allele-specific PCR

The paper develops an allele-specific PCR to subtype emm1 Streptococcus pyogenes isolates, finding M1UK lineage dominates invasive infections in England in 2020.

Diverse Genetic Determinants of Nitrofurantoin Resistance in UK Escherichia coli

This study identifies genetic factors causing nitrofurantoin resistance in UK E. coli, finding mutations and insertion sequences in nfsA and nfsB as major contributors.

RANKL from Bone Marrow Adipocytes Regulates Osteoclast Formation and Bone Loss in Mice

This study shows that RANKL from bone marrow adipocytes regulates trabecular osteoclast formation and bone loss in mice, with implications for therapeutic targeting of bone marrow adiposity.