Author

L. Game

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Vieira· 2 shared H. K. Li· 2 shared I. Andrew· 2 shared S. Sriskandan· 2 shared X. Zhi· 2 shared A. Fairweather· 1 shared A. Paccanaro· 1 shared A. Schricker· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersMicrobiology

A. Vieira

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Characterization of the RofA regulon in the pandemic M1global and emergent M1UK lineages of Streptococcus pyogenes

X. Zhi, A. Vieira, K. K. Huse, P. J. Martel, L. Lobkowicz, H. K. Li, N. Croucher, I. Andrew, L. Game, S. Sriskandan

This study characterizes the RofA regulon in two emm1 lineages of Streptococcus pyogenes, showing lineage-specific gene expression changes and potential regulatory impacts of SNPs in the PRD domain.

bioRxiv · Jul 23, 2023 · PreprintMicrobiology

Characterisation of emergent toxigenic M1UK Streptococcus pyogenes and associated sublineages

H. K. Li, X. Zhi, A. Vieira, H. J. Whitwell, A. Schricker, E. Jauneikaite, H. Li, A. Yosef, I. Andrew, L. Game, C. E. Turner, T. Lamagni, J. Coelho, S. Sriskandan

This study characterizes the M1UK sublineage of Streptococcus pyogenes, identifying genetic and phenotypic differences that contribute to its dominance and increased virulence.

bioRxiv · Dec 27, 2022Microbiology

Cellular barcoding of protozoan pathogens reveals the within-host population dynamics of Toxoplasma gondii host colonization

C. J. Wincott, G. Sritharan, H. J. Benns, F. B. Liakath, C. Gilabert-Carbajo, M. Bunyan, A. Fairweather, E. Alves, I. Andrews, L. Game, E. M. Frickel, C. Tiengwe, S. E. Ewald, M. A. Child

The paper develops a CRISPR-based barcoding method for protozoa and applies it to Toxoplasma gondii, showing the blood-brain barrier is not a major bottleneck for colonization.

bioRxiv · Aug 6, 2020Microbiology

Tracking Subclonal Mutation Frequencies Throughout Lymphomagenesis Identifies Cancer Drivers in Mouse Models of Lymphoma.

P. Webster, J. C. Dawes, H. Dewchand, K. Takacs, B. Iadarola, B. J. Bolt, J. J. Caceres, J. Kaczor, L. Game, T. Adejumo, J. Elliott, K. Naresh, G. Tan, G. Dharmalingam, A. Paccanaro, A. Uren

The paper tracks subclonal mutation frequencies in mouse lymphoma models to identify cancer drivers and demonstrates negative selection of potentially deleterious mutations.

bioRxiv · Jun 29, 2017Cancer Biology