S. Hui

A broadly-neutralizing antibody against Ebolavirus glycoprotein that potentiates the breadth and neutralization potency of other antibodies

The paper identifies two broadly neutralizing antibodies against Ebolavirus glycoprotein and shows that one enhances the neutralization breadth and potency of other antibodies.

Ongoing evolution of the Mycobacterium tuberculosis lactate dehydrogenase reveals the pleiotropic effects of bacterial adaption to host pressure

This study investigates the evolutionary adaptation of Mycobacterium tuberculosis lactate dehydrogenase (LldD2) under host pressure, showing its role in metabolic flexibility and virulence.

IL-6 is dispensable for causing cachexia in the colon carcinoma 26 model

This study shows that IL-6 is not required for cachexia in the C26 colon carcinoma model, as IL-6 knockout tumors still induce cachexia despite reduced tumor growth.

A liver-specific mitochondrial carrier that controls gluconeogenesis and energy expenditure

This study identifies SLC25A47 as a liver-specific mitochondrial carrier that regulates gluconeogenesis and energy expenditure by controlling pyruvate flux and FGF21 expression.

Structure of the Inmazeb cocktail and resistance to escape against Ebola virus

The paper presents the cryoEM structure of the Inmazeb cocktail in complex with Ebola virus glycoprotein, showing how the combination prevents escape mutations better than monotherapy.

Glycan shield of the ebolavirus envelope glycoprotein GP

This study profiles the site-specific glycosylation patterns of ebolavirus GP using mass spectrometry, revealing complex N-, O-, and C-linked glycans that contribute to the glycan shield and restrict antibody neutralization.

The Macromolecular MR Spectrum in Healthy Aging

This study acquires and analyzes the macromolecular MR spectrum in healthy adults across ages 20-69, finding no significant age or sex-related changes in macromolecule signals.

Comparison of different linear-combination modelling algorithms for short-TE proton spectra

This paper compares three linear-combination modelling algorithms for short-TE proton MRS spectra, finding moderate agreement in metabolite estimates but significant variability in Glx and mI across algorithms.

Structural Basis of Broad Ebolavirus Neutralization by a Human Survivor Antibody

The paper determines the structure of a broadly neutralizing antibody against ebolavirus, identifies a conserved epitope, and explains factors affecting its activity against related viruses.