Author

N. Ferreiros

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Assay:structural biology· 1

Frequent Co-Authors

C. Schneider· 2 shared D. Thomas· 2 shared G. Geisslinger· 2 shared J. Cinatl· 2 shared O. T. Keppler· 2 shared Y. Xiong· 2 shared B. Bilen· 1 shared D. Bojkova· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersPharmacology & Toxicology

C. Schneider

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2 papers

Recent·Most cited

Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells

T. Rothenburger, D. Thomas, Y. Schreiber, P. R. Wratil, T. Pflantz, K. Knecht, K. Digianantonio, J. Temple, C. Schneider, H.-M. Baldauf, K.-M. McLaughlin, F. Rothweiler, B. Bilen, S. Farmand, D. Bojkova, , J. Cinatl

This study identifies intrinsic and acquired resistance mechanisms to CNDAC and related nucleoside analogues in AML cells, showing distinct roles of SAMHD1 and DCK.

bioRxiv · Jul 19, 2021Pharmacology & Toxicology

The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1

K. M. Knecht, O. Buzovetsky, C. Schneider, D. Thomas, V. Srikanth, F. Tofoleanu, K. Reiss, N. Ferreiros, G. Geisslinger, V. S. Batista, X. Ji, J. Cinatl, O. T. Keppler, Y. Xiong

This study investigates how cancer drugs interact with SAMHD1's catalytic and allosteric sites, finding that drug efficacy is affected by SAMHD1 activity and that only cladribine-TP induces the active tetramer.

bioRxiv · Apr 6, 2018Biochemistry