Author

N. G. Seidah

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 5 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

D. Susan-Resiga· 4 shared R. Essalmani· 4 shared A. Evagelidis· 3 shared A. Delpal· 2 shared B. Coutard· 2 shared C. Mapa· 2 shared D. Huynh· 2 shared E. A. Cohen· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBiochemistry

D. Susan-Resiga

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Intermolecular proteolytic processing of SPRING and Site-1-protease regulate SREBP signaling

S. Hendrix, J. M. E. Tan, K. Ndoj, M. Valiloo, L. F. Zijlstra, R. Ottenhoff, N. G. Seidah, A. Loregger, N. Zelcer

This study shows SPRING and S1P interact, with SPRING cleavage by S1P facilitating S1P activation, but SPRING cleavage is not essential for SREBP signaling.

bioRxiv · Mar 28, 2023 · PreprintBiochemistry

Implications of Spike-glycoprotein processing at S1/S2 by Furin, at S2' by Furin and/or TMPRSS2 and shedding of ACE2: cell-to-cell fusion, cell entry and infectivity of SARS-CoV-2

R. Essalmani, J. Jain, D. Susan-Resiga, U. Andreo, A. Evagelidis, M. Derbali, D. Huynh, F. Dallaire, M. Laporte, A. Delpal, P. Sutto-Ortiz, B. Coutard, C. Mapa, K. Wilcoxen, E. Decroly, , N. G. Seidah

The paper discusses the implications of spike-glycoprotein processing by Furin and TMPRSS2 on SARS-CoV-2 infectivity and cell entry, but the manuscript has been withdrawn.

bioRxiv · Jul 2, 2021 · PreprintBiochemistry

Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLRthat is shed by Furin

D. Susan-Resiga, E. Girard, R. Essalmani, A. Roubtsova, J. Marcinkiewicz, R. M. Derbali, A. Evagelidis, J. H. Byun, P. F. Lebeau, R. C. Austin, N. G. Seidah

This paper identifies ASGR1 as a novel PCSK9-independent ligand of liver LDLR that is shed by Furin, leading to reduced LDLR levels and LDL uptake.

bioRxiv · Apr 11, 2021Biochemistry

In vivo analysis of the contribution of proprotein convertases to the processing of FGF23

O. Al Rifai, D. Susan-Resiga, R. Essalmani, J. Creemers, N. G. Seidah, M. Ferron

This study investigates the role of proprotein convertases in FGF23 processing in vivo, finding that furin contributes to cleavage under specific conditions but not universally.

bioRxiv · Jan 15, 2021Physiology

SARS-CoV-2 spike-glycoprotein processing at S1/S2 and S2' and shedding of the ACE2 viral receptor: roles of Furin and TMPRSS2 and implications for viral infectivity and cell-to-cell fusion

R. Essalmani, J. Jain, D. Susan-Resiga, U. Andreo, A. Evagelidis, R. M. Derbali, D. Huynh, F. Dallaire, M. Laporte, A. Delpal, P. Sutto-Ortiz, B. Coutard, C. Mapa, K. Wilcoxen, E. Decroly, , N. G. Seidah

This study investigates the roles of Furin and TMPRSS2 in SARS-CoV-2 spike protein processing and viral entry, showing their synergistic effects and suggesting combined inhibitors as antivirals.

bioRxiv · Dec 18, 2020 · PreprintBiochemistry

A novel cell-based sensor detecting the activity of individual basic proprotein convertases

K. I. Low, K. Hardes, C. Fedeli, N. G. Seidah, D. B. Constam, A. Pasquato, T. Steinmetzer, A. Roulin, S. Kunz

The paper introduces PCific, a cell-based sensor to screen and distinguish inhibitors of individual basic proprotein convertases in mammalian cells.

bioRxiv · Nov 6, 2018Biochemistry