Author

N. Guan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

A. S. Meyer· 2 shared A. Fang· 1 shared A. J. McMichael· 1 shared A. Lux· 1 shared B. D. Huisman· 1 shared B. Guo· 1 shared B. Yu· 1 shared C. Romagnani· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCancer Biology

A. S. Meyer

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

An unbiased characterization of the HLA-E and CD94/NKG2x peptide repertoire reveals peptide ligands that skew NK cell activation

B. D. Huisman, N. Guan, T. Ruckert, L. Garner, N. K. Singh, A. J. McMichael, G. M. Gillespie, C. Romagnani, M. E. Birnbaum

The paper identifies 500 HLA-E-bound peptides that bind CD94/NKG2A or CD94/NKG2C, revealing ligands that modulate NK cell activation.

bioRxiv · Aug 3, 2022Immunology

Porous microneedle patch with sustained exosome delivery repairs severe spinal cord injury

A. Fang, Y. Wang, N. Guan, L. Lin, B. Guo, W. Cai, X. Chen, J. Ye, Z. Abdelrahman, X. Li, Y. Zuo, H. Zheng, Z. Wu, S. Jin, K. Xu, , X. Wang

This study develops a microneedle patch that delivers mesenchymal stem cell-derived exosomes to treat spinal cord injury, showing improved tissue recovery and functional outcomes in rats.

bioRxiv · Jul 18, 2022 · PreprintBioengineering

Measurement and models accounting for cell death capture hidden variation in compound response

S. Y. Bae, N. Guan, R. Yan, K. Warner, A. S. Meyer

The paper shows that measuring only live cell numbers masks differences in compound effects and introduces an approach to include cell death in pharmacologic response analysis.

bioRxiv · Dec 4, 2019Cancer Biology

Dissecting FcγR Regulation Through a Multivalent Binding Model

R. A. Robinett, N. Guan, A. Lux, M. Biburger, F. Nimmerjahn, A. S. Meyer

This paper develops a multivalent binding model to predict FcγR-immune complex interactions and enables rational design of immune complexes for desired effector functions.

bioRxiv · Nov 27, 2017Immunology