Author

B. D. Huisman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:yeast· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Assay:CITE-seq· 1

Frequent Co-Authors

M. E. Birnbaum· 6 shared D. K. Gifford· 3 shared Z. Dai· 3 shared N. K. Singh· 2 shared A. J. McMichael· 1 shared B. Carter· 1 shared B. E. Grace· 1 shared B. H. Kang· 1 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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6 shared papersImmunology

M. E. Birnbaum

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6 papers

Recent·Most cited

Yeast display platform for expression of linear peptide epitopes to assess peptide-MHC-II binding in high-throughput

B. D. Huisman, P. A. Balivada, M. E. Birnbaum

This paper introduces a yeast display platform for high-throughput assessment of peptide-MHC-II binding by decoupling MHC-II expression from peptides.

bioRxiv · Aug 9, 2022Immunology

An unbiased characterization of the HLA-E and CD94/NKG2x peptide repertoire reveals peptide ligands that skew NK cell activation

B. D. Huisman, N. Guan, T. Ruckert, L. Garner, N. K. Singh, A. J. McMichael, G. M. Gillespie, C. Romagnani, M. E. Birnbaum

The paper identifies 500 HLA-E-bound peptides that bind CD94/NKG2A or CD94/NKG2C, revealing ligands that modulate NK cell activation.

bioRxiv · Aug 3, 2022Immunology

Identification of highly cross-reactive mimotopes for a public T cell response in murine melanoma

B. E. Grace, C. M. Backlund, D. M. Morgan, B. H. Kang, N. K. Singh, B. D. Huisman, C. G. Rappazzo, K. D. Moynihan, L. Maiorino, C. S. Dobson, T. Kyung, K. S. Gordon, P. V. Holec, O. C. T. Mbah, D. Garafola, , M. E. Birnbaum

The paper identifies a dominant tumor-associated antigen in murine melanoma and shows that engineered mimotopes can induce cross-reactive T cell responses.

bioRxiv · Feb 28, 2022Immunology

A high-throughput yeast display approach to profile pathogen proteomes for MHC-II binding

B. D. Huisman, Z. Dai, D. K. Gifford, M. E. Birnbaum

The paper presents a high-throughput yeast display method to assess MHC-II binding of peptides from SARS-CoV-2 and dengue virus, identifying binders missed by computational predictions.

bioRxiv · Feb 22, 2022Immunology

Extracting and Interpreting the Effects of Higher Order Sequence Features on Peptide MHC Binding

Z. Dai, B. D. Huisman, M. E. Birnbaum, D. K. Gifford

This paper extracts and interprets sequence features affecting peptide MHC binding using yeast display data, showing they accurately predict binding and align with structural knowledge.

bioRxiv · Nov 20, 2020 · PreprintImmunology

Machine learning optimization of peptides for presentation by class II MHCs

Z. Dai, B. D. Huisman, H. Zeng, B. Carter, S. Jain, M. E. Birnbaum, D. K. Gifford

The paper develops a machine learning method to optimize peptide binding to class II MHCs by modifying anchor residues, validated through a yeast display assay.

bioRxiv · Aug 18, 2020Immunology