Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
V. Meynier, S. W. Hardwick, M. Catala, J. Roske, S. Oerum, D. Y. Chirgadze, P. Barraud, W. Yue, B. Luisi, C. Tisne
This study reports cryo-EM structures of human mitochondrial tRNA maturation complexes, revealing the molecular mechanisms of tRNA processing steps and their sequential order.
Nature Communications · Jun 1, 2024Peer-reviewedBiochemistry
Y. Saucereau, T. H. Wilson, M. C. , K. Tang, M. C. Moncrieffe, S. W. Hardwick, D. Y. Chirgadze, S. G. Soares, M. J. Marcaida, N. J. Gay, M. Gangloff
The paper presents cryo-EM structures of Toll5A and Spaetzle1C complexes in Aedes aegypti, revealing their asymmetric interactions and distinct transcriptional roles in immune response.
bioRxiv · Sep 6, 2021Immunology
M. L. Kilkenny, C. E. Veale, A. Guppy, S. W. Hardwick, D. Y. Chirgadze, N. J. Rzechorzek, J. D. Maman, L. Pellegrini
This study reports the cryoEM structure of the SARS-CoV-2 nsp1-primosome complex, revealing how nsp1 interacts with the DNA polymerase-primase complex to disrupt immune responses.
bioRxiv · Jun 17, 2021 · PreprintBiophysics
T. Nakane, A. Kotecha, A. Sente, G. McMullan, S. Masiulis, P. M. G. E. Brown, I. T. Grigoras, L. Malinauskaite, T. Malinauskas, J. Miehling, L. Yu, D. Karia, E. V. Pechnikova, E. de Jong, J. Keizer, , S. Scheres
This paper demonstrates achieving atomic resolution cryo-EM structures for membrane proteins and apo-ferritin using advanced hardware, enabling detailed structural analysis and hydrogen bonding visualization.
Nature · Oct 21, 2020Peer-reviewedBiophysics
N. J. Rzechorzek, S. W. Hardwick, V. A. Jatikusumo, D. Y. Chirgadze, L. Pellegrini
The paper reports cryoEM structures of human CMG helicase bound to DNA and AND-1, revealing DNA binding interactions and replisome interactions.
bioRxiv · Jan 22, 2020Biochemistry