K. Sakamoto

Information structure of heterogeneous criticality in fish school

This study applies integrated information theory to fish school behavior, finding heterogeneous criticality with high-criticality subgroups coexisting with traditional criticality.

Personalized Molecular Signatures of Insulin Resistance and Type 2 Diabetes

The paper uses proteomics to identify personalized signatures of insulin resistance and type 2 diabetes, showing that fasting proteome and phosphoproteome predict insulin sensitivity and reveal sex-specific differences.

AlphaFold2 structures template ligand discovery

This study evaluates AlphaFold2 models for ligand discovery, finding they perform similarly to experimental structures despite conformational differences, and identify potent agonists for the 5-HT2A receptor.

Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets

This study shows that prior respiratory virus infections worsen measles severity in ferrets and that antiviral treatment can mitigate immune amnesia and disease outcomes regardless of treatment timing.

4-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses

This study shows 4-Fluorouridine effectively treats seasonal and highly pathogenic influenza viruses in cell culture, organoids, and animal models, preventing lethal infection and transmission.

AMPKα2 is a skeletal muscle stem cell intrinsic regulator of myonuclear accretion

This study shows that AMPKα2 regulates myonuclear accretion in muscle stem cells, essential for muscle regeneration.

Beyond pathologist-level annotation of large-scale cancer histology for semantic segmentation using immunofluorescence restaining

The paper develops SegPath, a large annotation dataset for histopathology segmentation, showing it outperforms pathologist annotations and reduces bias.

Autophagy promotes organelle clearance and organized cell separation of living root cap cells in Arabidopsis thaliana

The paper uses live-cell tracking to show autophagy facilitates organelle rearrangement and organized cell separation in Arabidopsis root cap cells during their functional transition.

SARS-CoV-2 variant of concern type and biological sex affect efficacy of molnupiravir in dwarf hamster model of severe COVID-19

This study evaluates molnupiravir efficacy against SARS-CoV-2 variants in different models, finding VOC-dependent efficacy and sex-based differences in dwarf hamsters.

Ambiguous Body Ownership Experience Caused by Feeling-judgement Conflict: Evidence from Subjective Measurement in Rubber Hand Illusion using Integrated Information Theory

This study uses integrated information theory to explain ambiguous body ownership in rubber hand illusions, finding that subjective experience correlates with {Phi} values.

Mechanism of glycogen synthase inactivation and interaction with glycogenin

The paper describes the cryo-EM structure of phosphorylated glycogen synthase and its interaction with glycogenin, revealing mechanisms of GS autoinhibition and regulation.

Experience resetting in reinforcement learning facilitates exploration-exploitation transitions during a behavioral task for primates

This study shows that experience resetting in reinforcement learning improves performance during exploration-exploitation transitions in primates using a target search task.

Immunisation of ferrets and mice with recombinant SARS-CoV-2 spike protein formulated with Advax-SM adjuvant protects against COVID-19 infection

This study develops a recombinant SARS-CoV-2 spike protein vaccine, Covax-19, formulated with Advax-SM adjuvant, showing protection against COVID-19 in mice and ferrets.

Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle

This study shows that AMPKγ3 is essential for AICAR-induced glucose clearance and uptake in glycolytic muscle but not for ADaM drug-induced effects or adipose thermogenesis.

Natural resistance to worms exacerbates bovine tuberculosis severity independently of worm coinfection

The paper shows that natural resistance to worms increases bovine tuberculosis severity, independent of active worm infection, with distinct pathological effects in lungs and lymph nodes.

AIRE is induced in oral squamous cell carcinoma and promotes cancer gene expression.

Addiction of mesenchymal phenotypes on the FGF/FGFR axis in oral squamous cell carcinoma cells

This study shows that autocrine FGF-FGFR(IIIc) signaling sustains ZEB1/2 expression and mesenchymal phenotypes in oral squamous cell carcinoma cells.