N. Malhotra

Uncovering the bequeathing potential of Apoptotic Mesenchymal Stem Cells via small Extracellular Vesicles for its enhanced immunomodulatory ability

This study compares the immunomodulatory and antioxidant effects of apoptotic and viable sEVs from bone marrow and Wharton's jelly MSCs in an in vitro liver injury model.

Determining the defining lengths between mature microRNAs/small interfering RNAs and tinyRNAs

The paper determines the minimum guide lengths required for miR-20a and let-7a to maintain their RISC conformation, finding 19 and 20 nt respectively, and identifies 17-nt guides as functional tinyRNAs (tyRNAs) without PAZ domain anchoring.

Emergence of networks of shared restriction-modification systems in phage-bacteria ecosystems

The paper analyzes RM system sharing in bacterial strains and models phage-bacteria dynamics to identify non-random network structures and two bacterial strategies.

Identification of SGLT2 inhibitor Ertugliflozin as a treatment for COVID-19 using computational and experimental paradigm

This study identifies Ertugliflozin as a potential treatment for COVID-19 through computational screening and experimental validation of its ability to inhibit RBD-ACE2 binding and modulate inflammatory responses.

Tyrosine Kinase Inhibitor Family of Drugs as Prospective Targeted Therapy for COVID-19 Based on In Silico And 3D-Human Vascular Lung Model Studies

This study evaluates four tyrosine kinase inhibitors for their anti-inflammatory and anti-thrombogenic effects against COVID-19 using in silico and 3D-human vascular lung models, suggesting they could be repurposed as targeted therapies.

In silico and in vitro Demonstration of Homoharrintonine Antagonism of RBD-ACE2 Binding and its Anti-inflammatory and anti-thrombogenic Properties in a 3D human vascular lung model

This paper identifies Homoharringtonine as a potential repurposed drug for COVID-19 by demonstrating its ability to block RBD-ACE2 binding and show anti-inflammatory and anti-thrombogenic effects in a 3D human vascular lung model.

Mycobacterium tuberculosis SufR Responds to Nitric oxide via its 4Fe-4S cluster and Regulates Fe-S cluster Biogenesis for Persistence in Mice

This paper shows that Mtb's SufR senses NO via its 4Fe-4S cluster, regulates Fe-S cluster biogenesis, and supports persistence in mice.

Neonatal-derived IL-17 producing dermal gd T cells are required to prevent spontaneous atopic dermatitis

This study shows that neonatal-derived IL-17-producing γδ T cells prevent spontaneous atopic dermatitis by maintaining skin homeostasis and preventing dysbiosis and inflammation.