Author

R. K. Jha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2 Pathology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

V. Nagaraja· 3 shared A. Singh· 2 shared K. Anand· 2 shared R. S. Rajmani· 2 shared A. Bhaskar· 1 shared A. Jamithireddy· 1 shared A. K. Mohan· 1 shared A. R. M. Bradbury· 1 shared

Activity by Year

2017-2021 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersMicrobiology

V. Nagaraja

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Identifying Key Determinants of SARS-CoV-2/ACE2 Tight Interaction

V. A. Ngo, R. K. Jha

This study identifies key residues in SARS-CoV-2 RBD that enhance binding to ACE2 compared to SARS-CoV through long simulations and force field comparisons.

PLOS ONE · Sep 28, 2021Peer-reviewedBiophysics

Engineered pH-Sensitive Protein G / IgG Interaction

R. K. Jha, A. Yankey, K. Shabazz, L. Naranjo, N. Velappan, A. R. M. Bradbury, C. E. M. Strauss

This paper designs a pH-sensitive Protein G-IgG interaction that shows a 50-fold change in binding affinity when pH shifts from acidic to basic.

bioRxiv · Dec 25, 2020Biochemistry

Study on the efficacy of Cynodon dactylon against Infectious Myonecrosis Virus (IMNV) in Penaeus vannamei

R. K. Jha, S. D. Wisoyo, K. Kristina, S. Srisombat

This study tests the antiviral effect of Cynodon dactylon extract on IMNV in shrimp, finding 98% survival rate with extract treatment.

bioRxiv · Nov 9, 2020 · PreprintPathology

Natural Oil Blend Formulation (NOBF) as an anti- African Swine Fever Virus (ASFV) agent in Primary Porcine Alveolar Macrophases (PAM) cells of Swine

H. Babikian, R. K. Jha, Q. L. Truong, L. T. Nguyen, H. T. Nguyen, T. L. To

This paper tests a natural oil blend (NOBF) against ASFV in porcine alveolar macrophages, finding it deactivates the virus at high dilutions.

bioRxiv · Oct 9, 2020Pathology

Mycobacterium tuberculosis SufR Responds to Nitric oxide via its 4Fe-4S cluster and Regulates Fe-S cluster Biogenesis for Persistence in Mice

K. Anand, A. Tripathi, K. Shukla, N. Malhotra, A. Jamithireddy, R. K. Jha, S. N. Chaudhury, R. S. Rajmani, A. Ramesh, V. Nagaraja, B. Gopal, G. Nagaraju, A. S. N. Seshasayee, A. Singh

This paper shows that Mtb's SufR senses NO via its 4Fe-4S cluster, regulates Fe-S cluster biogenesis, and supports persistence in mice.

bioRxiv · Aug 10, 2020 · PreprintMicrobiology

A multifunctional type IA DNA/RNA topoisomerase with RNA hydrolysis and rRNA processing activities from Mycobacterium smegmatis and Mycobacterium tuberculosis

P. Rani, S. M. Kalladi, H. Bansia, S. Rao, R. K. Jha, P. Jain, T. Bhaduri, V. Nagaraja

This study identifies a multifunctional DNA/RNA topoisomerase in mycobacteria that performs RNA hydrolysis and rRNA processing, highlighting its dual catalytic roles in RNA metabolism.

bioRxiv · Jul 13, 2020 · PreprintBiochemistry

Efficacy of the β-lactam\β-lactamase inhibitor combination is linked to WhiB4 mediated changes in redox physiology of Mycobacterium tuberculosis

S. Mishra, P. Shukla, A. Bhaskar, K. Anand, P. Baloni, R. K. Jha, A. K. Mohan, R. S. Rajmani, V. Nagaraja, N. Chandra, A. Singh

This paper shows that the effectiveness of the β-lactam/β-lactamase inhibitor combination against Mtb depends on WhiB4-regulated redox changes, with higher mycothiol redox potential enhancing drug efficacy.

eLife · May 26, 2017Peer-reviewedMicrobiology