Reciprocal interactions between the gut microbiome and mammary tissue mast cells promote metastatic dissemination of HR+ breast tumors
T.-Y. Feng, F. N. Azar, C. B. Rosean, M. T. McGinty, A. M. Putelo, S. Koli, N. Marino, R. German, R. Podicheti, S. A. Dreger, W. J. Fowler, S. Greenfield, S. D. Robinson, M. R. Rutkowski
This study shows that an inflammatory gut microbiome promotes early metastasis of HR+ breast tumors by increasing mast cell activity in mammary tissue.
bioRxiv · Dec 23, 2021Cancer Biology