Dystonia-associated Torsins sustain CLCC1 function to promote membrane fusion of the nuclear envelope for NPC biogenesis
Daria Maslennikova, Harry J. M. Baird, Alessia Loffreda, Kausthubh Ramachandran, Ashutosh Kumar, Jelmi uit de Bos, Caroline Ashiono, Katharina Frischer-Ordu, Naemi Luithle, Federico Uliana, Gautam Dey, Stefano Vanni, Madhav Jagannathan, Ulrike Kutay
This study identifies CLCC1 as a Torsin1A binding partner essential for nuclear envelope membrane fusion during NPC biogenesis, showing its therapeutic potential for DYT1 dystonia.
bioRxiv · Nov 7, 2025 · PreprintCell Biology