Jelmi uit de Bos

Dystonia-associated Torsins sustain CLCC1 function to promote membrane fusion of the nuclear envelope for NPC biogenesis

This study identifies CLCC1 as a Torsin1A binding partner essential for nuclear envelope membrane fusion during NPC biogenesis, showing its therapeutic potential for DYT1 dystonia.

Persistent contacts between Climp63 and microtubules cause mitotic defects and nuclear fragmentation

This study shows that a phosphodeficient Climp63 mutant causes mitotic delays and nuclear fragmentation by preventing the dissolution of ER-microtubule contacts during mitosis.

Condensin’s ATPase Machinery Drives and Dampens Mitotic Chromosome Condensation

This study shows that condensin complexes use opposing ATPase sites to drive and dampen chromosome condensation, with condensin II playing a key role in decatenation and axis formation.

Natural genetic variation in C. elegans reveals genomic loci controlling metabolite levels

The paper identifies genetic loci controlling metabolite levels in C. elegans using recombinant inbred lines and QTL mapping.