Eain A. Murphy

This study evaluates Brincidofovir's effects on glioblastoma, showing improved survival and both CMV-dependent and independent antitumor activity.

This paper identifies UL14 as a viral protein essential for HCMV infection of epithelial cells, showing its role in post-entry, pre-IE transcription and suggesting it as a potential target for antiviral therapies.

This study shows that protein-S-nitrosylation of HCMV pp65 reduces its ability to inhibit cGAS, thereby limiting viral replication and immune response evasion.

This study shows HSV-1 infection alters MAPT splicing, increases 4R-Tau protein and hyperphosphorylation, and promotes Tau pathology in neural models.

This study shows that proteasome inhibition reduces HCMV replication by lowering the effective multiplicity of infection, and synergizes with antiviral drugs.

This paper identifies SLC19A1 as a target of HSV-1 to inhibit antiviral responses mediated by extracellular 2-3cGAMP.

Inhibiting HSF1 reduces HCMV replication in vitro and in vivo by targeting an early stage of the viral replication cycle.