The structural basis for the selective antagonism of soluble TNF-alpha by shark variable new antigen receptors
Obinna C. Ubah, Eric W. Lake, Kendahl L. Ott, Stella Priyanka, Sasha Celeda, Jayden L. West, Gihan S. Gunaratne, Ke Shi, Nicholas H. Moeller, Andrew J. Porter, Hideki Aihara, David Kosoff, Aaron Matthew LeBeau, Caroline Jane Barelle
This study presents crystal structures of VNARs targeting sTNF- with distinct epitopes, showing selective antagonism without inducing reverse signaling.
Nature Communications · Nov 29, 2025Peer-reviewedPharmacology & Toxicology