The contribution of native protein complexes to targeted protein degradation
Lorraine Glennie, Nicole Curnutt, Gajanan Sathe, Brune Le Chatelier, Freya Goff, Jin-Feng Zhao, Tyrell N. Cartwright, Karen J. Dunbar, Nicola T. Wood, Thomas Macartney, Christina M. Woo, Gopal P. Sapkota
This study shows that molecular glue degraders targeting CK1 can co-degrade multiple SACK1 proteins, highlighting the role of protein complex context in targeted protein degradation.
ACS Chemical Biology · Apr 9, 2026Peer-reviewedCell Biology